The Effect of a TLR4 Agonist/Cationic Liposome Adjuvant on Varicella-Zoster Virus Glycoprotein E Vaccine Efficacy: Antigen Presentation, Uptake and Delivery to Lymph Nodes

The Effect of a TLR4 Agonist/Cationic Liposome Adjuvant on Varicella-Zoster Virus Glycoprotein E Vaccine Efficacy: Antigen Presentation, Uptake and Delivery to Lymph Nodes

Adjuvant CIA09, composed of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)-based cationic liposomes and the toll-like receptor 4 agonist de-<i>O</i>-acylated lipooligosaccharide (dLOS), has been shown to enhance antibody and cellular immune responses to varicella-zoster virus (VZV) gly...

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Bibliographic Details
Main Authors: Seo Ri Wui, Ara Ko, Ji In Ryu, Eojin Sim, Soo Jeong Lim, Shin Ae Park, Kwang Sung Kim, Ha Kim, Hyewon Youn, Na Gyong Lee
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
antigen delivery to lymph nodes
cationic liposomes
cellular antigen uptake
CIA09
TLR4 agonist de-<i>O</i>-acylated lipooligosaccharides
vaccine adjuvant
Online Access:https://www.mdpi.com/1999-4923/13/3/390

Internet

https://www.mdpi.com/1999-4923/13/3/390

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