Treg-Resistant Cytotoxic CD4<sup>+</sup> T Cells Dictate T Helper Cells in Their Vicinity: TH17 Skewing and Modulation of Proliferation

Treg-Resistant Cytotoxic CD4<sup>+</sup> T Cells Dictate T Helper Cells in Their Vicinity: TH17 Skewing and Modulation of Proliferation

Cytotoxic CD4<sup>+</sup> T cells (CD4 CTL) are terminally differentiated T helper cells that contribute to autoimmune diseases, such as multiple sclerosis. We developed a novel triple co-culture transwell assay to study mutual interactions between CD4 CTL, conventional TH cells, and reg...

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Bibliographic Details
Main Authors: Cindy Hoeks, Marjan Vanheusden, Liesbet M. Peeters, Piet Stinissen, Bieke Broux, Niels Hellings
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
cytotoxic CD4 T cells
CD4 CTL
regulatory CD4 T cells
suppression
proliferation
autoimmunity
Online Access:https://www.mdpi.com/1422-0067/22/11/5660

Internet

https://www.mdpi.com/1422-0067/22/11/5660

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