Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

Abstract ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA). For this reason, ADAMTS-5 is a pharmaceutical target for the treatment of OA....

Full description

Bibliographic Details
Main Authors: Salvatore Santamaria, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Tiziano Tuccinardi, Francesca Liva, Felicia D’Andrea, Rens de Groot, Armando Rossello, Josefin Ahnström
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-80294-1

Internet

https://doi.org/10.1038/s41598-020-80294-1

Similar Items