Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain

Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain

The ability of the fungal pathogen Candida albicans to undergo yeast-to-hypha transition is believed to be a key virulence factor. Here, Dunker et al. show that a filament-deficient strain is attenuated in a mouse model of intraperitoneal infection, but remains virulent in a mouse model of systemic...

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Bibliographic Details
Main Authors: Christine Dunker, Melanie Polke, Bianca Schulze-Richter, Katja Schubert, Sven Rudolphi, A. Elisabeth Gressler, Tony Pawlik, Juan P. Prada Salcedo, M. Joanna Niemiec, Silvia Slesiona-Künzel, Marc Swidergall, Ronny Martin, Thomas Dandekar, Ilse D. Jacobsen
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24095-8

Internet

https://doi.org/10.1038/s41467-021-24095-8

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