Transversions have larger regulatory effects than transitions

Transversions have larger regulatory effects than transitions

Abstract Background Transversions (Tv’s) are more likely to alter the amino acid sequence of proteins than transitions (Ts’s), and local deviations in the Ts:Tv ratio are indicative of evolutionary selection on genes. Whether the two different types of mutations have different effects in non-protein...

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Bibliographic Details
Main Authors: Cong Guo, Ian C. McDowell, Michael Nodzenski, Denise M. Scholtens, Andrew S. Allen, William L. Lowe, Timothy E. Reddy
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Genomics
Subjects:
Transitions
Transversions
Massively parallel reporter assay
SNPs
Regulatory variation
Online Access:http://link.springer.com/article/10.1186/s12864-017-3785-4

Internet

http://link.springer.com/article/10.1186/s12864-017-3785-4

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