Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.

Chronic exposure to inducers of DNA base oxidation and single and double strand breaks contribute to tumorigenesis. In addition to the genetic changes caused by this DNA damage, such tumors often contain epigenetically silenced genes with aberrant promoter region CpG island DNA hypermethylation. We...

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Bibliographic Details
Main Authors: Heather M O'Hagan, Helai P Mohammad, Stephen B Baylin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2491723?pdf=render

Internet

http://europepmc.org/articles/PMC2491723?pdf=render

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