Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation and Coagulation

Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation and Coagulation

Abstract The identification of HMGB1 as a late mediator in sepsis has highlighted HMGB1 as a promising therapeutic target for sepsis treatment. Recent studies have revealed that annexin A5, a 35 kDa Ca2+-dependent phospholipid binding protein, exerts antiinflammatory effect by inhibiting LPS binding...

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Bibliographic Details
Main Authors: Jung Hwa Park, Jong-Hwa Jang, Eun Jung Choi, Young Seob Kim, Eun Ji Lee, In Duk Jung, Hee Dong Han, T-C Wu, Chien-Fu Hung, Tae Heung Kang, Yeong-Min Park
Format: Article
Language:English
Published: BMC 2016-07-01
Series:Molecular Medicine
Online Access:http://link.springer.com/article/10.2119/molmed.2016.00026

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http://link.springer.com/article/10.2119/molmed.2016.00026

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