Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in a neurodevelopmental disorder characterized by early-onset intractable seizures, severe developmental delay, intellectual disability, and Rett's syndrome-like features. Since the physiological function...

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Bibliographic Details
Main Authors: Claudia Fuchs, Stefania Trazzi, Roberta Torricella, Rocchina Viggiano, Marianna De Franceschi, Elena Amendola, Cornelius Gross, Laura Calzà, Renata Bartesaghi, Elisabetta Ciani
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Neurobiology of Disease
Subjects:
CDKL5 disorder
Rett's syndrome
Neurodevelopmental disorders
Neurogenesis impairment
Dendritic development
AKT/GSK-3β signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001703

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http://www.sciencedirect.com/science/article/pii/S0969996114001703

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