Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling
Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in a neurodevelopmental disorder characterized by early-onset intractable seizures, severe developmental delay, intellectual disability, and Rett's syndrome-like features. Since the physiological function...
Main Authors: | Claudia Fuchs, Stefania Trazzi, Roberta Torricella, Rocchina Viggiano, Marianna De Franceschi, Elena Amendola, Cornelius Gross, Laura Calzà, Renata Bartesaghi, Elisabetta Ciani |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-10-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996114001703 |
Similar Items
-
Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder
by: Claudia Fuchs, et al.
Published: (2015-10-01) -
Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of <i>CDKL5</i> Deficiency Disorder
by: Manuela Loi, et al.
Published: (2021-05-01) -
Lack of Cdkl5 disrupts the organization of excitatory and inhibitory synapses and parvalbumin interneurons in the primary visual cortex
by: Riccardo Pizzo, et al.
Published: (2016-11-01) -
X-linked cellular mosaicism underlies age-dependent occurrence of seizure-like events in mouse models of CDKL5 deficiency disorder
by: Barbara Terzic, et al.
Published: (2021-01-01) -
<it>CDKL5</it> gene status in female patients with epilepsy and Rett-like features: two new mutations in the catalytic domain
by: Maortua Hiart, et al.
Published: (2012-08-01)