Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency

Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency

Lymphostromal cross-talk in the thymus is essential to allow generation of a diversified repertoire of T lymphocytes and to prevent autoimmunity by self-reactive T cells. Hypomorphic mutations in genes that control T cell development have been associated with immunodeficiency and immune dysregulatio...

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Bibliographic Details
Main Authors: Francesca eRucci, Pietro Luigi Poliani, Stefano eCaraffi, Tiziana ePaganini, Elena eFontana, Silvia eGiliani, Frederick W Alt, Luigi Daniele Notarangelo
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-05-01
Series:Frontiers in Immunology
Subjects:
Dendritic Cells
Severe Combined Immunodeficiency
regulatory T cells
AIRE
Thymus
DNA Ligase 4
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00015/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00015/full

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