From Inflammation to the Onset of Fibrosis through A<sub>2A</sub> Receptors in Kidneys from Deceased Donors

From Inflammation to the Onset of Fibrosis through A<sub>2A</sub> Receptors in Kidneys from Deceased Donors

Pretransplant graft inflammation could be involved in the worse prognosis of deceased donor (DD) kidney transplants. A2A adenosine receptor (A<sub>2A</sub>R) can stimulate anti-inflammatory M2 macrophages, leading to fibrosis if injury and inflammation persist. Pre-implantation biopsies...

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Bibliographic Details
Main Authors: Elena Guillén-Gómez, Irene Silva, Núria Serra, Francisco Caballero, Jesús Leal, Alberto Breda, Rody San Martín, Marçal Pastor-Anglada, José A. Ballarín, Lluís Guirado, Montserrat M. Díaz-Encarnación
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
fibrosis
macrophage
inflammation
transplant
kidney
purinome
Online Access:https://www.mdpi.com/1422-0067/21/22/8826

Internet

https://www.mdpi.com/1422-0067/21/22/8826

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