The C proteins of human parainfluenza virus type 1 block IFN signaling by binding and retaining Stat1 in perinuclear aggregates at the late endosome.

The C proteins of human parainfluenza virus type 1 block IFN signaling by binding and retaining Stat1 in perinuclear aggregates at the late endosome.

Interferons (IFNs) play a crucial role in the antiviral immune response. Whereas the C proteins of wild-type human parainfluenza virus type 1 (WT HPIV1) inhibit both IFN-β induction and signaling, a HPIV1 mutant encoding a single amino acid substitution (F170S) in the C proteins is unable to block e...

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Bibliographic Details
Main Authors: Henrick Schomacker, Rebecca M Hebner, Jim Boonyaratanakornkit, Sonja Surman, Emerito Amaro-Carambot, Peter L Collins, Alexander C Schmidt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3280236?pdf=render

Internet

http://europepmc.org/articles/PMC3280236?pdf=render

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