Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy

Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy

The tumorigenicity and toxicity of induced pluripotent stem cells (iPSCs) and their derivatives are major safety concerns in their clinical application. Recently, we developed granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing proliferating myeloid cells (GM-pMCs) from mouse iPSCs a...

Full description

Bibliographic Details
Main Authors: Hiroaki Mashima, Rong Zhang, Tsuyoshi Kobayashi, Hirotake Tsukamoto, Tianyi Liu, Tatsuaki Iwama, Yuichiro Hagiya, Masateru Yamamoto, Satoshi Fukushima, Seiji Okada, Alimjan Idiris, Shin Kaneko, Tetsuya Nakatsura, Hideki Ohdan, Yasushi Uemura
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
cancer immunotherapy
induced pluripotent stem cell
antigen-presenting cell
granulocyte-macrophage colony-stimulating factor
c-Myc
suicide gene
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000413

Internet

http://www.sciencedirect.com/science/article/pii/S2329050121000413

Similar Items