Brain alterations in high fat diet induced obesity: effects of tart cherry seeds and juice
Evidence suggests that obesity adversely affects brain function. High body mass index, hypertension, dyslipidemia, insulin resistance, and diabetes are risk factors for increasing cognitive decline. Tart cherries (<i>Prunus</i><i> </i><i>Cerasus</i> L.) are rich i...
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doaj-56eb2935c9254df4a5cd88fdfa8bd0332020-11-25T02:56:04ZengMDPI AGNutrients2072-66432020-02-0112362310.3390/nu12030623nu12030623Brain alterations in high fat diet induced obesity: effects of tart cherry seeds and juiceMaria Vittoria Micioni Di Bonaventura0Ilenia Martinelli1Michele Moruzzi2Emanuela Micioni Di Bonaventura3Maria Elena Giusepponi4Carlo Polidori5Giulio Lupidi6Seyed Khosrow Tayebati7Francesco Amenta8Carlo Cifani9Daniele Tomassoni10School of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, ItalySchool of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, ItalyDepartment of Medicine, University of Leipzig, Liebigstraße 21, 04103 Leipzig, GermanySchool of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, ItalySchool of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, ItalySchool of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, ItalySchool of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, ItalySchool of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, ItalySchool of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, ItalySchool of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri, 9, 62032 Camerino, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, via Gentile III da Varano, 62032 Camerino, ItalyEvidence suggests that obesity adversely affects brain function. High body mass index, hypertension, dyslipidemia, insulin resistance, and diabetes are risk factors for increasing cognitive decline. Tart cherries (<i>Prunus</i><i> </i><i>Cerasus</i> L.) are rich in anthocyanins and components that modify lipid metabolism. This study evaluated the effects of tart cherries on the brain in diet-induced obese (DIO) rats. DIO rats were fed with a high-fat diet alone or in association with a tart cherry seeds powder (DS) and juice (DJS). DIO rats were compared to rats fed with a standard diet (CHOW). Food intake, body weight, fasting glycemia, insulin, cholesterol, and triglycerides were measured. Immunochemical and immunohistochemical techniques were performed. Results showed that body weight did not differ among the groups. Blood pressure and glycemia were decreased in both DS and DJS groups when compared to DIO rats. Immunochemical and immunohistochemical techniques demonstrated that in supplemented DIO rats, the glial fibrillary acid protein expression and microglial activation were reduced in both the hippocampus and in the frontal cortex, while the neurofilament was increased. Tart cherry intake modified aquaporin 4 and endothelial inflammatory markers. These findings indicate the potential role of this nutritional supplement in preventing obesity-related risk factors, especially neuroinflammation.https://www.mdpi.com/2072-6643/12/3/623diet-induced obese ratshigh fat dietbrainneuroinflammationobesitytart cherries |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Vittoria Micioni Di Bonaventura Ilenia Martinelli Michele Moruzzi Emanuela Micioni Di Bonaventura Maria Elena Giusepponi Carlo Polidori Giulio Lupidi Seyed Khosrow Tayebati Francesco Amenta Carlo Cifani Daniele Tomassoni |
spellingShingle |
Maria Vittoria Micioni Di Bonaventura Ilenia Martinelli Michele Moruzzi Emanuela Micioni Di Bonaventura Maria Elena Giusepponi Carlo Polidori Giulio Lupidi Seyed Khosrow Tayebati Francesco Amenta Carlo Cifani Daniele Tomassoni Brain alterations in high fat diet induced obesity: effects of tart cherry seeds and juice Nutrients diet-induced obese rats high fat diet brain neuroinflammation obesity tart cherries |
author_facet |
Maria Vittoria Micioni Di Bonaventura Ilenia Martinelli Michele Moruzzi Emanuela Micioni Di Bonaventura Maria Elena Giusepponi Carlo Polidori Giulio Lupidi Seyed Khosrow Tayebati Francesco Amenta Carlo Cifani Daniele Tomassoni |
author_sort |
Maria Vittoria Micioni Di Bonaventura |
title |
Brain alterations in high fat diet induced obesity: effects of tart cherry seeds and juice |
title_short |
Brain alterations in high fat diet induced obesity: effects of tart cherry seeds and juice |
title_full |
Brain alterations in high fat diet induced obesity: effects of tart cherry seeds and juice |
title_fullStr |
Brain alterations in high fat diet induced obesity: effects of tart cherry seeds and juice |
title_full_unstemmed |
Brain alterations in high fat diet induced obesity: effects of tart cherry seeds and juice |
title_sort |
brain alterations in high fat diet induced obesity: effects of tart cherry seeds and juice |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-02-01 |
description |
Evidence suggests that obesity adversely affects brain function. High body mass index, hypertension, dyslipidemia, insulin resistance, and diabetes are risk factors for increasing cognitive decline. Tart cherries (<i>Prunus</i><i> </i><i>Cerasus</i> L.) are rich in anthocyanins and components that modify lipid metabolism. This study evaluated the effects of tart cherries on the brain in diet-induced obese (DIO) rats. DIO rats were fed with a high-fat diet alone or in association with a tart cherry seeds powder (DS) and juice (DJS). DIO rats were compared to rats fed with a standard diet (CHOW). Food intake, body weight, fasting glycemia, insulin, cholesterol, and triglycerides were measured. Immunochemical and immunohistochemical techniques were performed. Results showed that body weight did not differ among the groups. Blood pressure and glycemia were decreased in both DS and DJS groups when compared to DIO rats. Immunochemical and immunohistochemical techniques demonstrated that in supplemented DIO rats, the glial fibrillary acid protein expression and microglial activation were reduced in both the hippocampus and in the frontal cortex, while the neurofilament was increased. Tart cherry intake modified aquaporin 4 and endothelial inflammatory markers. These findings indicate the potential role of this nutritional supplement in preventing obesity-related risk factors, especially neuroinflammation. |
topic |
diet-induced obese rats high fat diet brain neuroinflammation obesity tart cherries |
url |
https://www.mdpi.com/2072-6643/12/3/623 |
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