Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.

Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.

Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no causal relationship has been established.We investigated the relationship between mtDNA mu...

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Bibliographic Details
Main Authors: Asimina Hiona, Alberto Sanz, Gregory C Kujoth, Reinald Pamplona, Arnold Y Seo, Tim Hofer, Shinichi Someya, Takuya Miyakawa, Chie Nakayama, Alejandro K Samhan-Arias, Stephane Servais, Jamie L Barger, Manuel Portero-Otín, Masaru Tanokura, Tomas A Prolla, Christiaan Leeuwenburgh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2898813?pdf=render

Internet

http://europepmc.org/articles/PMC2898813?pdf=render

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