Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of Nucleophosmin in human cardiac mesenchymal progenitor cells

Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of Nucleophosmin in human cardiac mesenchymal progenitor cells

Abstract Background Doxorubicin (Dox) is an anti-cancer anthracycline drug that causes double-stranded DNA breaks. It is highly effective against several types of tumours; however, it also has adverse effects on regenerative populations of normal cells, such as human cardiac mesenchymal progenitor c...

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Bibliographic Details
Main Authors: Sara Beji, Marco D’Agostino, Elisa Gambini, Sara Sileno, Alessandro Scopece, Maria Cristina Vinci, Giuseppina Milano, Guido Melillo, Monica Napolitano, Giulio Pompilio, Maurizio C. Capogrossi, Daniele Avitabile, Alessandra Magenta
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Biology
Subjects:
Doxorubicin
Anthracyclines
Ultraviolet radiation
Alarmin
Cardiotoxicity
Online Access:https://doi.org/10.1186/s12915-021-01058-5

Internet

https://doi.org/10.1186/s12915-021-01058-5

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