An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity.

The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify signal joint T cell receptor excision circles (sj...

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Bibliographic Details
Main Authors: Angela Holder, Stephanie Mella, Donald B Palmer, Richard Aspinall, Brian Catchpole
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5100965?pdf=render