Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

Dysfunction of the blood-brain barrier (BBB) contributes significantly to the pathogenesis of several neuroinflammatory diseases, including multiple sclerosis (MS). Potential players that regulate BBB function are the liver X receptors (LXRs), which are ligand activated transcription factors compris...

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Bibliographic Details
Main Authors: Elien Wouters, Nienke M. de Wit, Jasmine Vanmol, Susanne M. A. van der Pol, Bert van het Hof, Daniela Sommer, Melanie Loix, Dirk Geerts, Jan Ake Gustafsson, Knut R. Steffensen, Tim Vanmierlo, Jeroen F. J. Bogie, Jerome J. A. Hendriks, Helga E. de Vries
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
blood-brain barrier
permeability
endothelium
liver X receptors
neuroinflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01811/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01811/full

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