Template-switching artifacts resemble alternative polyadenylation

Template-switching artifacts resemble alternative polyadenylation

Abstract Background Alternative polyadenylation is commonly examined using cDNA sequencing, which is known to be affected by template-switching artifacts. However, the effects of such template-switching artifacts on alternative polyadenylation are generally disregarded, while alternative polyadenyla...

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Bibliographic Details
Main Authors: Zsolt Balázs, Dóra Tombácz, Zsolt Csabai, Norbert Moldován, Michael Snyder, Zsolt Boldogkői
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Genomics
Subjects:
Template switching
Polyadenylation
RNA sequencing
Long-read sequencing
Direct RNA sequencing
Internal priming
Online Access:http://link.springer.com/article/10.1186/s12864-019-6199-7

Internet

http://link.springer.com/article/10.1186/s12864-019-6199-7

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