Impairment of early fracture healing by skeletal muscle trauma is restored by FK506

Impairment of early fracture healing by skeletal muscle trauma is restored by FK506

Abstract Background Heightened local inflammation due to muscle trauma or disease is associated with impaired bone regeneration. Methods We hypothesized that FK506, an FDA approved immunomodulatory compound with neurotrophic and osteogenic effects, will rescue the early phase of fracture healing whi...

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Bibliographic Details
Main Authors: Brady J. Hurtgen, Beth E. P. Henderson, Catherine L. Ward, Stephen M. Goldman, Koyal Garg, Todd O. McKinley, Sarah M. Greising, Joseph C. Wenke, Benjamin T. Corona
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Musculoskeletal Disorders
Subjects:
Adaptive immune response
Composite injury
Inflammation
Immunomodulation
Musculoskeletal
Open fracture
Online Access:http://link.springer.com/article/10.1186/s12891-017-1617-y

Internet

http://link.springer.com/article/10.1186/s12891-017-1617-y

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