Quantitative control of noise in mammalian gene expression by dynamic histone regulation

Quantitative control of noise in mammalian gene expression by dynamic histone regulation

Fluctuation ('noise') in gene expression is critical for mammalian cellular processes. Numerous mechanisms contribute to its origins, yet the mechanisms behind large fluctuations that are induced by single transcriptional activators remain elusive. Here, we probed putative mechanisms by st...

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Bibliographic Details
Main Authors: Deng Tan, Rui Chen, Yuejian Mo, Shu Gu, Jiao Ma, Wei Xu, Xibin Lu, Huiyu He, Fan Jiang, Weimin Fan, Yili Wang, Xi Chen, Wei Huang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
epigenetic bistability
gene expression noise
histone modification
transcriptional activator
synthetic circuit
oscillation
Online Access:https://elifesciences.org/articles/65654

Internet

https://elifesciences.org/articles/65654

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