Ru(II)-Thymine Complex Causes Cell Growth Inhibition and Induction of Caspase-Mediated Apoptosis in Human Promyelocytic Leukemia HL-60 Cells

Ru(II)-Thymine Complex Causes Cell Growth Inhibition and Induction of Caspase-Mediated Apoptosis in Human Promyelocytic Leukemia HL-60 Cells

Ruthenium-based compounds represent a class of potential antineoplastic drugs. Recently, we designed, synthesized, and identified the Ru(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh = triphenylphosphine, Thy = thymine and bipy = 2,2′-bipyridine) as a potent cytotoxic agent with...

Full description

Bibliographic Details
Main Authors: Maiara de Souza Oliveira, Ádila Angélica Dantas de Santana, Rodrigo S. Correa, Milena Botelho Pereira Soares, Alzir Azevedo Batista, Daniel Pereira Bezerra
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
ruthenium
thymine
cytotoxicity
apoptosis
HL-60
Online Access:http://www.mdpi.com/1422-0067/19/6/1609

Internet

http://www.mdpi.com/1422-0067/19/6/1609

Similar Items