Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

Environmental toxicants and, in particular, pesticides have been implicated as risk factors in Parkinson's disease (PD). The purpose of this study was to determine if selective nigrostriatal degeneration could be reproduced by systemic exposure of mice to the widely used herbicide paraquat. Rep...

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Bibliographic Details
Main Authors: Alison L. McCormack, Mona Thiruchelvam, Amy B. Manning-Bog, Christine Thiffault, J.William Langston, Deborah A. Cory-Slechta, Donato A. Di Monte
Format: Article
Language:English
Published: Elsevier 2002-07-01
Series:Neurobiology of Disease
Subjects:
dopamine
pesticide
substantia nigra
striatum
GABA
stereology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905073

Internet

http://www.sciencedirect.com/science/article/pii/S0969996102905073

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