New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali

New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali

Abstract Background Encoded by the var gene family, highly variable Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) proteins mediate tissue-specific cytoadherence of infected erythrocytes, resulting in immune evasion and severe malaria disease. Sequencing and assembling the 40–60 var g...

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Bibliographic Details
Main Authors: Antoine Dara, Elliott F. Drábek, Mark A. Travassos, Kara A. Moser, Arthur L. Delcher, Qi Su, Timothy Hostelley, Drissa Coulibaly, Modibo Daou, Ahmadou Dembele, Issa Diarra, Abdoulaye K. Kone, Bourema Kouriba, Matthew B. Laurens, Amadou Niangaly, Karim Traore, Youssouf Tolo, Claire M. Fraser, Mahamadou A. Thera, Abdoulaye A. Djimde, Ogobara K. Doumbo, Christopher V. Plowe, Joana C. Silva
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Genome Medicine
Subjects:
Malaria
Plasmodium falciparum
Plasmodium falciparum erythrocyte membrane protein-1
PfEMP1
var
var2csa
Online Access:http://link.springer.com/article/10.1186/s13073-017-0422-4

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http://link.springer.com/article/10.1186/s13073-017-0422-4

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