Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Serine synthesis from glucose is required even when serine is available from the environment. Here, the authors explain this paradox by showing that the enzyme PHGDH enables nucleotide synthesis by coordinating anabolic fluxes related to central carbon metabolism, independent of its role in serine p...

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Bibliographic Details
Main Authors: Michael A. Reid, Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu, Luhua Lai, Jason W. Locasale
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07868-6

Internet

https://doi.org/10.1038/s41467-018-07868-6

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