SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway

SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway

Sirtuin 5 (SIRT5), a mitochondrial class III NAD-dependent deacetylase, plays controversial roles in tumorigenesis and chemoresistance. Accordingly, its role in ovarian cancer development and drug resistance is not fully understood. Here, we demonstrate that SIRT5 is increased in ovarian cancer tiss...

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Bibliographic Details
Main Authors: Xiaodan Sun, Shouhan Wang, Junda Gai, Jingqian Guan, Ji Li, Yizhuo Li, Jinming Zhao, Chen Zhao, Lin Fu, Qingchang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
ovarian cancer
SIRT5
Nrf2/HO-1
reactive oxygen species
drug resistance
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00754/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00754/full

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