Mutations in the <i>ND2</i> Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells

Mutations in the <i>ND2</i> Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells

Multiprotein complexes of the mitochondrial electron transport chain form associations to generate supercomplexes. The relationship between tumor cell ability to assemble mitochondrial supercomplexes, tumorigenesis and metastasis has not been studied thoroughly. The mitochondrial and metabolic diffe...

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Bibliographic Details
Main Authors: Joaquín Marco-Brualla, Sameer Al-Wasaby, Ruth Soler, Eduardo Romanos, Blanca Conde, Raquel Justo-Méndez, José A. Enríquez, Patricio Fernández-Silva, Luis Martínez-Lostao, Martín Villalba, Raquel Moreno-Loshuertos, Alberto Anel
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
mitochondria
dichloroacetate
complex I
<i>ND2</i>
metastasis
cybrids
Online Access:https://www.mdpi.com/2072-6694/11/7/1027

Internet

https://www.mdpi.com/2072-6694/11/7/1027

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