The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species

The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species

Methyl-aminolevulinate-based photodynamic therapy (MAL-PDT) is utilised clinically for the treatment of non-melanoma skin cancers and pre-cancers and the hydroxypyridinone iron chelator, CP94, has successfully been demonstrated to increase MAL-PDT efficacy in an initial clinical pilot study. However...

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Bibliographic Details
Main Authors: Yuktee Dogra, Daniel C.J. Ferguson, Nicholas J.F. Dodd, Gary R. Smerdon, Alison Curnow, Paul G. Winyard
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Redox Biology
Subjects:
Apoptosis
Electron paramagnetic resonance (EPR) spectrometry
Necrosis
Photodynamic therapy (PDT)
Protoporphyrin IX (PpIX)
Reactive oxygen species (ROS)
Skin cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300635

Internet

http://www.sciencedirect.com/science/article/pii/S2213231716300635

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