Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APPSwe/PSEN1M146V transgenic miceResearch in context

Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APPSwe/PSEN1M146V transgenic miceResearch in context

Background: Progression of Alzheimer's disease is thought initially to depend on rising amyloidβ and its synaptic interactions. Transgenic mice (TASTPM; APPSwe/PSEN1M146V) show altered synaptic transmission, compatible with increased physiological function of amyloidβ, before plaques are detect...

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Bibliographic Details
Main Authors: Evelyn Medawar, Tiffanie A. Benway, Wenfei Liu, Taylor A. Hanan, Peter Haslehurst, Owain T. James, Kenrick Yap, Laurenz Muessig, Fabia Moroni, Muzammil A. Nahaboo Solim, Gaukhar Baidildinova, Rui Wang, Jill C. Richardson, Francesca Cacucci, Dervis A. Salih, Damian M. Cummings, Frances A. Edwards
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418305772

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http://www.sciencedirect.com/science/article/pii/S2352396418305772

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