Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

Abstract Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that contribute to tumor progression and therapy resistance. However, the underlying processes are still unclear. Elucidation of the key hallmarks and resistance mechanisms of CSCs may help improve patient o...

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Bibliographic Details
Main Authors: He-Ming Zhou, Ji-Gang Zhang, Xue Zhang, Qin Li
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-020-00430-1