Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA

Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA

Familial amyotrophic lateral sclerosis (FALS) has been modeled in transgenic mice by introducing mutated versions of human genomic DNA encompassing the entire gene for Cu,Zn superoxide dismutase (SOD1). In this setting, the transgene is expressed throughout the body and results in mice that faithful...

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Bibliographic Details
Main Authors: Jiou Wang, Guilian Xu, Hilda H. Slunt, Victoria Gonzales, Michael Coonfield, David Fromholt, Neal G. Copeland, Nancy A. Jenkins, David R. Borchelt
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neurobiology of Disease
Subjects:
FALS
Superoxide dismutase
Protein aggregation
Transgenic mice
Disease model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001646

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http://www.sciencedirect.com/science/article/pii/S0969996105001646

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