Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines.

Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines.

The tumor suppressor Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers. Alterations in Protein kinase C (PKC) isozyme expression and aberrant regulation also comprise early events in intestinal carcinomas. Here we show that PKCδ expression levels are decreased in colon t...

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Bibliographic Details
Main Authors: José G Hernández-Maqueda, Luis Bernardo Luna-Ulloa, Paula Santoyo-Ramos, M Cristina Castañeda-Patlán, Martha Robles-Flores
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3592802?pdf=render

Internet

http://europepmc.org/articles/PMC3592802?pdf=render

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