Evolutionary sequence modeling for discovery of peptide hormones.

Evolutionary sequence modeling for discovery of peptide hormones.

There are currently a large number of "orphan" G-protein-coupled receptors (GPCRs) whose endogenous ligands (peptide hormones) are unknown. Identification of these peptide hormones is a difficult and important problem. We describe a computational framework that models spatial structure alo...

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Bibliographic Details
Main Authors: Kemal Sonmez, Naunihal T Zaveri, Ilan A Kerman, Sharon Burke, Charles R Neal, Xinmin Xie, Stanley J Watson, Lawrence Toll
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19132080/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19132080/pdf/?tool=EBI

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