Stiffness analysis of 3D spheroids using microtweezers.

We describe a novel mechanical characterization method that has directly measured the stiffness of cancer spheroids for the first time to our knowledge. Stiffness is known to be a key parameter that characterizes cancerous and normal cells. Atomic force microscopy or optical tweezers have been typic...

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Bibliographic Details
Main Authors: Devina Jaiswal, Norah Cowley, Zichao Bian, Guoan Zheng, Kevin P Claffey, Kazunori Hoshino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5699838?pdf=render