Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice[S]

Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice[S]

Chronic elevations of plasma apolipoprotein B (apoB) are strongly associated with cardiovascular disease. We have previously demonstrated that inhibition of hepatic apoB mRNA using antisense oligonucleotides (ASO) results in reductions of apoB, VLDL, and LDL in several preclinical animal models and...

Full description

Bibliographic Details
Main Authors: Adam E. Mullick, Wuxia Fu, Mark J. Graham, Richard G. Lee, Donna Witchell, Thomas A. Bell, Charles P. Whipple, Rosanne M. Crooke
Format: Article
Language:English
Published: Elsevier 2011-05-01
Series:Journal of Lipid Research
Subjects:
antisense oligonucleotides
apolipoprotein B
hypercholesterolemia
lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408752

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520408752

Similar Items