C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity.

C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity.

Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus of peptides or proteins. CPM is thought to be involved in inflammatory processes. This is corroborated by CPM-mediated trimming and modulation of inflammatory factors, and expression of the protease...

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Bibliographic Details
Main Authors: Catherine Denis, Kathleen Deiteren, Anneleen Mortier, Amel Tounsi, Erik Fransen, Paul Proost, Jean-Christophe Renauld, Anne-Marie Lambeir
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22479563/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22479563/?tool=EBI

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