A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease

A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease

Based on the pathophysiological role of adenosine A2A receptors in HD, we have evaluated the association of the 1976C/T single-nucleotide polymorphism in the ADORA2A gene (rs5751876) with residual age at onset (AAO) in HD. The study population consisted of 791 unrelated patients belonging to the Hun...

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Bibliographic Details
Main Authors: Claire-Marie Dhaenens, Sylvie Burnouf, Clémence Simonin, Edwige Van Brussel, Alain Duhamel, Luc Defebvre, Cécile Duru, Isabelle Vuillaume, Cécile Cazeneuve, Perrine Charles, Patrick Maison, Sabrina Debruxelles, Christophe Verny, Hélène Gervais, Jean-Philippe Azulay, Christine Tranchant, Anne-Catherine Bachoud-Levi, Alexandra Dürr, Luc Buée, Pierre Krystkowiak, Bernard Sablonnière, David Blum
Format: Article
Language:English
Published: Elsevier 2009-09-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
A2A receptors
Polymorphism
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610900165X

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http://www.sciencedirect.com/science/article/pii/S096999610900165X

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