Targeting Aspergillus fumigatus Crf Transglycosylases With Neutralizing Antibody Is Relevant but Not Sufficient to Erase Fungal Burden in a Neutropenic Rat Model

Targeting Aspergillus fumigatus Crf Transglycosylases With Neutralizing Antibody Is Relevant but Not Sufficient to Erase Fungal Burden in a Neutropenic Rat Model

Aspergillus fumigatus is an airborne opportunistic fungal pathogen responsible for severe infections. Among them, invasive pulmonary aspergillosis has become a major concern as mortality rates exceed 50% in immunocompromised hosts. In parallel, allergic bronchopulmonary aspergillosis frequently enco...

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Bibliographic Details
Main Authors: David Chauvin, Michael Hust, Mark Schütte, Adélaïde Chesnay, Christelle Parent, Gustavo Marçal Schmidt Garcia Moreira, Javier Arroyo, Ana Belén Sanz, Martine Pugnière, Pierre Martineau, Jacques Chandenier, Nathalie Heuzé-Vourc’h, Guillaume Desoubeaux
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Microbiology
Subjects:
Aspergillus
fungi
invasive pulmonary aspergillosis
cell wall
Crf1
Crh5
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00600/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00600/full

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