Truncated tau deregulates synaptic markers in rat model for human tauopathy

Truncated tau deregulates synaptic markers in rat model for human tauopathy

Synaptic failure and neurofibrillary degeneration are two major neuropathological substrates of cognitive dysfunction in Alzheimer’s disease (AD). Only a few studies have demonstrated a direct relationship between these two AD hallmarks. To investigate tau mediated synaptic injury we used rat model...

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Bibliographic Details
Main Authors: Santosh eJadhav, Stanislav eKatina, Andrej eKovac, Zuzana eKazmerova, Michal eNovak, Norbert eZilka
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer Disease
Phosphorylation
Truncated tau
synaptic damage
tau mislocalization
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00024/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00024/full

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