Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep

Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep

Background: Toll-like receptor (TLR) agonists are key immunomodulatory factors that can markedly ameliorate or exacerbate hypoxic–ischemic brain injury. We recently demonstrated that central infusion of the TLR7 agonist Gardiquimod (GDQ) following asphyxia was highly neuroprotective after 3 days but...

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Bibliographic Details
Main Authors: Kenta H.T. Cho, Mhoyra Fraser, Bing Xu, Justin M. Dean, Alistair J. Gunn, Laura Bennet
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
cardiovascular
electrophysiology
fetal sheep
hypoxia–ischemia
Toll-like receptors
Online Access:https://www.mdpi.com/1422-0067/22/12/6593

Internet

https://www.mdpi.com/1422-0067/22/12/6593

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