MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

Abstract Background Targeted therapies are based on exploiting cancer-cell-specific genetic features or phenotypic traits to selectively kill cancer cells while leaving normal cells unaffected. Oxidative stress is a cancer hallmark phenotype. Given that free nucleotide pools are particularly vulnera...

Full description

Bibliographic Details
Main Authors: Hussein H. K. Abbas, Kheloud M. H. Alhamoudi, Mark D. Evans, George D. D. Jones, Steven S. Foster
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
Lung cancer
MTH1
NUDT1
Targeted therapy
Nucleotides
Oxidative DNA damage
Online Access:http://link.springer.com/article/10.1186/s12885-018-4332-7

Internet

http://link.springer.com/article/10.1186/s12885-018-4332-7

Similar Items