Leishmania-Specific Promiscuous Membrane Protein Tubulin Folding Cofactor D Divulges Th1/Th2 Polarization in the Host via ERK-1/2 and p38 MAPK Signaling Cascade

Leishmania-Specific Promiscuous Membrane Protein Tubulin Folding Cofactor D Divulges Th1/Th2 Polarization in the Host via ERK-1/2 and p38 MAPK Signaling Cascade

Visceral leishmaniasis (VL)-related mortality and morbidity imposes a great deal of health concern across the globe. The existing anti-leishmanial drug regimen generally fails to eliminate newly emerging resistant isolates of this dreadful parasite. In such circumstances, the development of a prophy...

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Bibliographic Details
Main Authors: Fauzia Jamal, Manish K. Singh, Jagadish Hansa, Pushpanjali, Ghufran Ahmad, Manas Ranjan Dikhit, Mohd Saad Umar, Sanjiva Bimal, Pradeep Das, Anzar Abdul Mujeeb, Shubhankar K. Singh, Swaleha Zubair, Mohammad Owais
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
tubulin folding cofactor D
Leishmania donovani
immunoprophylaxis
Th1 response
T-cell proliferation
MAPK signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00817/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00817/full

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