Lipopolysaccharide renders transgenic mice expressing human serum amyloid P component sensitive to Shiga toxin 2.

Lipopolysaccharide renders transgenic mice expressing human serum amyloid P component sensitive to Shiga toxin 2.

Transgenic C57BL/6 mice expressing human serum amyloid P component (HuSAP) are resistant to Shiga toxin 2 (Stx2) at dosages that are lethal in HuSAP-negative wild-type mice. However, it is well established that Stx2 initiates extra-intestinal complications such as the haemolytic-uremic syndrome desp...

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Bibliographic Details
Main Authors: Thomas P Griener, Jonathan G Strecker, Romney M Humphries, George L Mulvey, Carmen Fuentealba, Robert E W Hancock, Glen D Armstrong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3123346?pdf=render

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http://europepmc.org/articles/PMC3123346?pdf=render

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