ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence

ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence

Replication stress induced by nucleotide deficiency plays an important role in cancer initiation. Replication stress in primary cells typically activates the cellular senescence tumor-suppression mechanism. Senescence bypass correlates with development of cancer, a disease characterized by metabolic...

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Bibliographic Details
Main Authors: Katherine M. Aird, Andrew J. Worth, Nathaniel W. Snyder, Joyce V. Lee, Sharanya Sivanand, Qin Liu, Ian A. Blair, Kathryn E. Wellen, Rugang Zhang
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715003897

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http://www.sciencedirect.com/science/article/pii/S2211124715003897

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