Lack of Cell Cycle Inhibitor p21 and Low CD4+ T Cell Suppression in Newborns After Exposure to IFN-β

Lack of Cell Cycle Inhibitor p21 and Low CD4+ T Cell Suppression in Newborns After Exposure to IFN-β

Type I IFNs, such as interferon alpha and interferon beta, are key regulators of the adaptive immune response during infectious diseases. Type I IFNs are induced upon infection, bind interferon α/β receptors on T-cells and activate intracellular pathways. The activating and inhibitory consequences o...

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Bibliographic Details
Main Authors: Jop Jans, Wendy W. Unger, Elisabeth A. M. Raeven, Elles R. Simonetti, Marc J. Eleveld, Ronald de Groot, Marien I. de Jonge, Gerben Ferwerda
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
interferon beta
respiratory syncytial virus
newborns
immunity
CD4 T cells
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.652965/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.652965/full

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