Panax quinquefolius L. Saponins Protect Myocardial Ischemia Reperfusion No-Reflow Through Inhibiting the Activation of NLRP3 Inflammasome via TLR4/MyD88/NF-κB Signaling Pathway

Panax quinquefolius L. Saponins Protect Myocardial Ischemia Reperfusion No-Reflow Through Inhibiting the Activation of NLRP3 Inflammasome via TLR4/MyD88/NF-κB Signaling Pathway

At present, many patients who undergo reperfusion immediately after percutaneous coronary intervention will undergo microvascular obstruction and reduction in myocardial blood flow. This phenomenon is called “no-reflow (NR),” and there is still no effective therapy for NR. Studies showed Panax quinq...

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Bibliographic Details
Main Authors: Ping Yu, Yuangeng Li, Wenwen Fu, Xin Li, Yanzhe Liu, Yaozhen Wang, Xiaofeng Yu, Huali Xu, Dayun Sui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
panax quinquefolius L. saponin
myocardial ischemia reperfusion no-reflow
inflammatory response
leukocytes
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.607813/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.607813/full

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