Histone H3 Cleavage in Severe COVID-19 ICU Patients

Histone H3 Cleavage in Severe COVID-19 ICU Patients

The severity of coronavirus disease 19 (COVID-19) is associated with neutrophil extracellular trap (NET) formation. During NET formation, cytotoxic extracellular histones are released, the presence of which is linked to the initiation and progression of several acute inflammatory diseases. Here we s...

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Bibliographic Details
Main Authors: Joram Huckriede, Femke de Vries, Michael Hultström, Kanin Wichapong, Chris Reutelingsperger, Miklos Lipcsey, Pablo Garcia de Frutos, Robert Frithiof, Gerry A. F. Nicolaes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
extracellular histones
DAMPs (damage-associated molecular patterns)
COVID-19
NETosis
ICU - intensive care unit
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.694186/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.694186/full

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