Low-Molecular-Weight Fucoidan Induces Endothelial Cell Migration via the PI3K/AKT Pathway and Modulates the Transcription of Genes Involved in Angiogenesis

Low-Molecular-Weight Fucoidan Induces Endothelial Cell Migration via the PI3K/AKT Pathway and Modulates the Transcription of Genes Involved in Angiogenesis

Low-molecular-weight fucoidan (LMWF) is a sulfated polysaccharide extracted from brown seaweed that presents antithrombotic and pro-angiogenic properties. However, its mechanism of action is not well-characterized. Here, we studied the effects of LMWF on cell signaling and whole genome expression in...

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Bibliographic Details
Main Authors: Claire Bouvard, Isabelle Galy-Fauroux, Françoise Grelac, Wassila Carpentier, Anna Lokajczyk, Sophie Gandrille, Sylvia Colliec-Jouault, Anne-Marie Fischer, Dominique Helley
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Marine Drugs
Subjects:
fucoidan
angiogenesis
vasculogenesis
migration
signaling
transcriptomics
Online Access:http://www.mdpi.com/1660-3397/13/12/7075

Internet

http://www.mdpi.com/1660-3397/13/12/7075

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