AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer

AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer

Summary: The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of stemness traits in cancer by co-option of a regulatory function normal...

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Bibliographic Details
Main Authors: Agnete S.T. Engelsen, Katarzyna Wnuk-Lipinska, Sebastien Bougnaud, Fanny A. Pelissier Vatter, Crina Tiron, René Villadsen, Masaru Miyano, Maria L. Lotsberg, Noëlly Madeleine, Pouda Panahandeh, Sushil Dhakal, Tuan Zea Tan, Stacey D’mello Peters, Sturla Grøndal, Sura M. Aziz, Silje Nord, Lars Herfindal, Martha R. Stampfer, Therese Sørlie, Rolf A. Brekken, Oddbjørn Straume, Nils Halberg, Gro Gausdal, Jean Paul Thiery, Lars A. Akslen, Ole W. Petersen, Mark A. LaBarge, James B. Lorens
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Cell Biology
Stem Cells Research
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308415

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http://www.sciencedirect.com/science/article/pii/S2589004220308415

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