Wnt/β-Catenin Inhibition Disrupts Carboplatin Resistance in Isogenic Models of Triple-Negative Breast Cancer

Wnt/β-Catenin Inhibition Disrupts Carboplatin Resistance in Isogenic Models of Triple-Negative Breast Cancer

Triple-Negative Breast Cancer (TNBC) is the most aggressive breast cancer subtype, characterized by limited treatment options and higher relapse rates than hormone-receptor-positive breast cancers. Chemotherapy remains the mainstay treatment for TNBC, and platinum salts have been explored as a thera...

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Bibliographic Details
Main Authors: Willy Antoni Abreu de Oliveira, Stijn Moens, Youssef El Laithy, Bernard K. van der Veer, Paraskevi Athanasouli, Emanuela Elsa Cortesi, Maria Francesca Baietti, Kian Peng Koh, Juan-Jose Ventura, Frédéric Amant, Daniela Annibali, Frederic Lluis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
triple negative breast cancer
WNT pathway
platinum-resistance
cancer stem cells
patient-derived xenograft models
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.705384/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.705384/full

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